Anemia of chronic disease is typically classified as which MCV category?

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Multiple Choice

Anemia of chronic disease is typically classified as which MCV category?

Explanation:
Anemia of chronic disease is usually normocytic, meaning the red blood cells are of normal size (MCV about 80–100 fL). Inflammation drives iron sequestration and reduces iron availability for erythropoiesis, while inflammatory cytokines blunt the erythropoietin response. This combination lowers hemoglobin without necessarily shrinking or enlarging the cells in early stages, so the MCV stays in the normal range. If iron deficiency develops on top of chronic disease, microcytosis can occur, but the classic presentation is normocytic. Macrocytic would point toward vitamin B12 or folate deficiency, and hypocytic isn’t a standard descriptor for this condition.

Anemia of chronic disease is usually normocytic, meaning the red blood cells are of normal size (MCV about 80–100 fL). Inflammation drives iron sequestration and reduces iron availability for erythropoiesis, while inflammatory cytokines blunt the erythropoietin response. This combination lowers hemoglobin without necessarily shrinking or enlarging the cells in early stages, so the MCV stays in the normal range. If iron deficiency develops on top of chronic disease, microcytosis can occur, but the classic presentation is normocytic. Macrocytic would point toward vitamin B12 or folate deficiency, and hypocytic isn’t a standard descriptor for this condition.

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