CA-125 elevations occur in which conditions?

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Multiple Choice

CA-125 elevations occur in which conditions?

Explanation:
CA-125 is a marker produced by cells lining the peritoneum, pleura, and endometrium. Its levels rise when there is irritation or inflammation of the peritoneal surfaces, not just with cancer. Endometriosis causes inflammatory irritation of the peritoneum due to ectopic endometrial tissue, which commonly elevates CA-125. Uterine fibroids can also be associated with peritoneal irritation, especially when large or degenerating, leading to modest increases. Liver disease, particularly with ascites, irritates the peritoneum and raises CA-125 as well. Pregnancy can sometimes cause mild elevations, but the pattern most consistently observed in this context involves endometriosis, fibroids, and liver disease.

CA-125 is a marker produced by cells lining the peritoneum, pleura, and endometrium. Its levels rise when there is irritation or inflammation of the peritoneal surfaces, not just with cancer.

Endometriosis causes inflammatory irritation of the peritoneum due to ectopic endometrial tissue, which commonly elevates CA-125. Uterine fibroids can also be associated with peritoneal irritation, especially when large or degenerating, leading to modest increases. Liver disease, particularly with ascites, irritates the peritoneum and raises CA-125 as well.

Pregnancy can sometimes cause mild elevations, but the pattern most consistently observed in this context involves endometriosis, fibroids, and liver disease.

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