Which of the following is a negative acute-phase reactant?

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Multiple Choice

Which of the following is a negative acute-phase reactant?

Explanation:
During an acute inflammatory response, the liver shifts its protein production: some proteins rise to help fight infection (positive acute-phase proteins) while others fall (negative acute-phase proteins). Albumin decreases because inflammatory cytokines, especially IL-6, downregulate its synthesis in the liver and its distribution can shift into the interstitial space due to increased vascular permeability. The other listed proteins—CRP, fibrinogen, and ferritin—are positive acute-phase proteins and rise in inflammation to support defense, clotting, and iron handling. Thus, albumin is the negative acute-phase reactant.

During an acute inflammatory response, the liver shifts its protein production: some proteins rise to help fight infection (positive acute-phase proteins) while others fall (negative acute-phase proteins). Albumin decreases because inflammatory cytokines, especially IL-6, downregulate its synthesis in the liver and its distribution can shift into the interstitial space due to increased vascular permeability. The other listed proteins—CRP, fibrinogen, and ferritin—are positive acute-phase proteins and rise in inflammation to support defense, clotting, and iron handling. Thus, albumin is the negative acute-phase reactant.

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